Finally, I’d like to offer a small pissing contest. It takes me: • 30 sec to draw THC • 38 sec to draw Penicillin G • 82 sec to draw discodermolide What about you? The compounds should be drawn with all stereochemical information and in the same general style (bond angles, side chains positioning) as in the picture below.
PMR: some of the blogosphere responded and the times were similar. What about non-graphical input such as SMILES or even WLN (which Depth-First resurrected: Everything Old is New Again: Wiswesser Line Notation (WLN) ? Of course WLN doesn’t do stereo, but I bet the practitioners could beat the times above by some considerable margin. And it wouldn’t be too difficult to include the stereo – in the last 40 years we have lowercase letters on our keyboards! And it took me 27 seconds to type the SMILES for penicillin (admittedly without stereo and orientation). But, as readers of this blog know, I can’t type either.